IndraLab

Statements

PPP1 dephosphorylates KCNB1. 5 / 5
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"In order to confirm that PP1 is dephosphorylating Kv2.1 in response to increases in activity, we pretreated neurons with 500 nM okadaic acid, a PP1 inhibitor."
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"A previous investigation may shed some light into which cytosolic residues of Kv2.1 may be dephosphorylated by PP1 [ xref ]."
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"Moreover, it appears that activity-induced dephosphorylation of Kv2.1 by PP1 is different from dephosphorylation observed in response to ischemic/pathological models induced via bath glutamate [ xref ] or bath NMDA ( xref and xref ) stimulation."
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sparser
"Dephosphorylation of Kv2.1 by PP1 in response to synaptic activity results in substantial shifts in the inactivation curve of I K , resulting in a reduction in intrinsic excitability, facilitating negative feedback to neuronal excitability."
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sparser
"Thus it appears that bicuculline treatment induced shifts I K toward hyperpolarizing conditions through dephosphorylation of Kv2.1 by PP1."
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