IndraLab

Statements

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"Arsenic trioxide and probucol were reported to accelerate hERG protein degradation from the cell membrane (2, 23)."
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"Consistent with these findings, in this study, we reported that As2O3 inhibited hERG channel at both protein and mRNA levels and damaged hERG current but did not affect channel kinetics."
25395240
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"In addition, knock-down of miR-21 by its specific antisense molecules AMO-21 was able to rescue Sp1 and hERG inhibition caused by As2O3."
25395240
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"This finding revealed that regulation of the NF-kappaB-miR-21-Sp1 signalling pathway is a novel mechanism for As2O3 induced hERG inhibition."
25395240
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"And the hERG channel inhibition induced by As2O3 was rescued after being transfected with AMO-23a, which may be a molecular mechanism for the role of As2O3 in hERG trafficking deficiency."
25395240
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"In our study, we found a new pathway underlying As2O3 induced cardiotoxicity that As2O3 accelerates lysosomal degradation of hERG on plasma membrane after using brefeldin A (BFA) to block protein trafficking."
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"Arsenic trioxide was shown to reduce the formation of hERG–chaperone (Hsp90 and Hsp70) complexes, resulting in disruption of hERG trafficking ( Ficker et al., 2004 )."
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"Arsenic trioxide and pentamidine inhibit hERG protein trafficking rather than directly inhibiting the channel action ( Ficker et al., 2004; Cordes et al., 2005 )."
20951697
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"Arsenic trioxide and pentamidine inhibit hERG protein trafficking rather than directly inhibiting the channel action ( Ficker et al., 2004; Cordes et al., 2005 )."
20951697
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"Arsenic trioxide inhibits the trafficking of hERG channels from the endoplasmic reticulum to the cell membrane [XREF_BIBR]."
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