IndraLab

Statements

reach
"Arsenic trioxide inhibits the trafficking of hERG channels from the endoplasmic reticulum to the cell membrane [XREF_BIBR]."
26926294
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"In addition, knock-down of miR-21 by its specific antisense molecules AMO-21 was able to rescue Sp1 and hERG inhibition caused by As2O3."
25395240
ctd
No evidence text available
25107562
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"Consistent with these findings, in this study, we reported that As2O3 inhibited hERG channel at both protein and mRNA levels and damaged hERG current but did not affect channel kinetics."
25395240
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"Arsenic trioxide (As (2) O (3)), which is used to treat acute promyelocytic leukemia, can cause LQTS type 2 (LQT2) by reducing the hERG current through the diversion of hERG trafficking to the cytoplasmic membrane."
23103450
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"This finding revealed that regulation of the NF-kappaB-miR-21-Sp1 signalling pathway is a novel mechanism for As2O3 induced hERG inhibition."
25395240
reach
"And the hERG channel inhibition induced by As2O3 was rescued after being transfected with AMO-23a, which may be a molecular mechanism for the role of As2O3 in hERG trafficking deficiency."
25395240
reach
"In our study, we found a new pathway underlying As2O3 induced cardiotoxicity that As2O3 accelerates lysosomal degradation of hERG on plasma membrane after using brefeldin A (BFA) to block protein trafficking."
28521025
ctd
No evidence text available
25395240