IndraLab

Statements

USP22 activates DNA repair. 5 / 5
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"It is likely that changes in USP22 and RNF40 status due to altered levels of m A may direct the DNA repair machinery to employ or not employ HR or NHEJ to repair damaged DNA."
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"USP22 can also enhance the telomerase reverse transcriptase (TERT)/p53 signaling pathway [ 65 ] and promote cell proliferation and DNA repair (see Fig. 1 )."
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"Furthermore, USP22 can regulate DNA repair events by targeting the deubiquitination of proteins other than H2A (22, 23, 37, 45), it is possible that in addition to H2Aub, other USP22 target proteins may contribute to ALKBH5’s DNA repair and oncogenic functions."
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"Unlike the mechanism of 5-FU drug resistance, USP22 enhances a tumor's DNA repair ability and decreases its sensitivity to cisplatin."
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"Unlike 5-FU resistance mechanisms, USP22 increases tumor resistance to cisplatin by enhancing DNA repair capacity."
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