IndraLab

Statements

MDM2 binds USP2. 11 / 12
5 1 | 3 2
reach
"For example, USP2 interacts and stabilizes fatty acid synthase [8], MDM2 [21], MDMX [22], Cyclin D1 [23], Aurora-A [24], Smad4 [25], and β-catenin [26]."
37628997
biogrid
No evidence text available
17290220
biogrid
No evidence text available
17290220
biogrid
No evidence text available
17290220
biogrid
No evidence text available
35253629
biogrid
No evidence text available
17290220
hprd
No evidence text available
17290220
reach
"The C-terminal region of USP2 forms part of the catalytic domain and binds to the C-terminal Zinc and Ring finger domain of mdm2, the same region of mdm2 that we demonstrated to bind to USP7.Crystal s[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20816748
reach
"Specifically, protein-protein interaction assays using the bacterial two-hybrid system showed that USP2 can deubiquitinate MDM2 and promotes p53 degradation, showing the association between USP2 and MDM2 (Stevenson et al., 2007)."
34539442
sparser
"Subsequent analysis demonstrated that USP2 can bind and deubiquitinate Mdm2."
32201366
sparser
"USP2 binds to Cyclin D1 and Mdm2 and induces their deubiquitination and stabilization, and its silencing causes downregulation of Cyclin D1 and Mdm2, leading to inhibiting cell proliferation ( xref ; xref )."
20531303