IndraLab

Statements

USP7 activates CHEK1. 3 / 3
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"Conversely, knockdown of USP7 in SUM159-P2 cells reduced CHK1 stability (XREF_FIG and XREF_SUPPLEMENTARY) but not ZEB1 stability (XREF_SUPPLEMENTARY)."
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"Cartel et al. found that CHK1 is a substrate of USP7, and USP7 modulates the protein stability of CHK1."
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"Two E3 ligase complexes, CUL4A and DDB1 and CUL1 and FBXO6, have shown to be responsible for Chk1 polyubiquitination and degradation; whereas deubiquitinases (DUB), USP1 and USP7, have been reported to promote Chk1 stabilization."
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