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Cadmium atom activates KCNH2. 5 / 5
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"The ability of Cd 2+ to increase HERG K + current appeared critically dependent upon channel inactivation, and both the increase in current and the accelerated rate of current decay were lost when ina[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"A simple mechanism by which Cd 2+ could increase HERG currents is to decrease the probability that the channels inactivate."
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"Surprisingly, 200 mu M Cd 2+ enhanced HERG outward currents at most tested membrane potentials."
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"At low concentrations (10-200 mu M), Cd 2+ enhanced HERG currents without shifting the voltage dependence of activation."
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"The present study illustrates that low concentrations of extracellular Cd 2+ modulated voltage dependent HERG inactivation independently of channel activation."
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