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Statements

USP22 increases the amount of TGFB. 5 / 5
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"In addition to promoting EMT, USP22 overexpression upregulated the expression of TGF-β1 and ECM components including FN, Collagen I, and Collagen Ⅳ under HG conditions ( Fig. 3 F)."
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"WB results further showed that USP22 overexpression downregulated E-cadherin and ZO-1 expression, upregulated Vimentin expression ( Fig. 6 C), and upregulated the expression of TGF-β1 and ECM componen[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"A recent study suggested that USP22 could increase TGF-beta expression and promote the epithelial-mesenchymal transition (EMT)."
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"IHC staining and WB results also showed that USP22 deficiency increased the protein expressions of E-cadherin and ZO-1, decreased the protein expression of α-SMA and Vimentin ( Fig. 10 C and D), and r[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The overexpression of USP22 can promote EMT occurrence and increase TGF-β1 expression in tumor cells ( Hu et al., 2015 )."
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