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USP8 inhibits Ubiquitin. 8 / 8
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"These results suggest that the CCL5 gene is activated in an NF-κB–dependent manner in USP8-depleted cells.Since USP8 depletion causes the accumulation of K63 ubiquitin chains on endosomes, we hypothesized that the K63 ubiquitin signals directly activate NF-κB via ubiquitin decoders."
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"This zinc-finger ribbon (observed also in USP2, USP8 and USP21 structures) is in the contracted ' closed-hand ' configuration seen in USP8, which was proposed to block ubiquitin access XREF_BIBR."
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"This zinc-finger ribbon seems to be in the contracted " closed-hand " configuration seen in USP8 that blocks ubiquitin access (XREF_FIG)."
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"The results indicated that USP8 directly eliminated the ubiquitin chain of OGT in a dose-dependent way (Fig. 4C)."
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"In 30–60% of ACTH-secreting PitNETs, dysregulation of ubiquitin-specific protease 8 (USP8) and the epidermal growth factor receptor (EGFR) pathway, neither of which are implicated in fetal corticotroph development, play a significant role [43,43]."
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"siRNA-mediated depletion of USP8 increased the cellular abundance of K63 ubiquitin chains by ∼50% (from ∼5 to ∼7.5 fmol per 1 µg of total cell lysate) compared with control cells, whereas little change was observed in the level of K48 ubiquitin chains (Fig. 1 A)."
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"In Drosophila melanogaster, UBPY silencing enhanced neurodegenerative TDP-43 phenotypes and the accumulation of insoluble high molecular weight TDP-43 and ubiquitin species."
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"These data clearly demonstrate that the decrease in USP8 activity causes K63 ubiquitin accumulation on early endosomes via defects in the endosomal sorting machinery, consistent with previous reports (Lobert et al., 2010; Mizuno et al., 2006; Row et al., 2006)."
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