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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

E3_Ub_ligase activates ATXN3. 2 / 2

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"Transient overexpression of the co-chaperone and E3 ligase C-terminus of HSC70 interacting protein (CHIP) increases the ubiquitination and clearance of polyQ expanded Htt and ataxin-3 in a cell culture model."

25674046

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"ER associated E3 ubiquitin ligase Autocrine Motility Factor Receptor (AMFR) or Gp78 induces the degradation of Superoxide Dismutase 1 (SOD1) and ataxin-3 and provides cytoprotection against mutant SOD1 induced toxicity XREF_BIBR."

24865853

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...