IndraLab

Statements

E3_Ub_ligase inhibits KCNH2. 3 / 3
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"Correspondingly, the drugs were observed to significantly enhance the time-dependent reduction of mature hERG channel proteins under the condition of inhibiting forward protein trafficking, thus indic[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We previously showed that the E3 ubiquitin ligase Nedd4-2 mediates degradation of hERG channels."
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"Two E3 ubiquitin ligases, Hrd1 and Doa10 are known to mediate the proteasomal degradation of HMG-CoA reductase Hmg2 and squalene epoxidase Erg1 with accumulation of the toxic sterols in cells, but the deubiquitinases (DUBs) involved are unclear."
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