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OTUD5 binds MAP3K7. 7 / 7
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"We confirmed the endogenous interaction between OTUD5 and TAK1 in podocytes using a Co-immunoprecipitation (co-IP) assay (Fig.  xref )."
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"Similarly, endogenous OTUD5 and TAK1 could form a complex in mouse kidney tissues (Fig.  xref )."
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"Moreover, Flag-OTUD5 and His-TAK1 plasmids were co-transfected into NIH/3T3 cells, confirming the exogenous interaction between OTUD5 and TAK1 (Fig.  xref )."
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"Therefore, we hypothesize that OTUD5 negatively regulates inflammation and injury through deubiquitinating TAK1 in podocytes.We confirmed the endogenous interaction between OTUD5 and TAK1 in podocytes using a Co-immunoprecipitation (co-IP) assay (Fig. 4c)."
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"Similarly, endogenous OTUD5 and TAK1 could form a complex in mouse kidney tissues (Fig. 4d)."
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"Moreover, Flag-OTUD5 and His-TAK1 plasmids were co-transfected into NIH/3T3 cells, confirming the exogenous interaction between OTUD5 and TAK1 (Fig. 4e)."
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"Mechanistically, we demonstrated that OTUD5 directly interacts with TAK1 and reduces K63-linked polyubiquitination of TAK1 at residue K158 through its active site C224, subsequently inhibiting the TAK1-mediated inflammatory response and injury in podocytes."
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