IndraLab

Statements

SPRTN binds VCPIP1. 10 / 10
1 | 5 4
reach
"Consistent with the interaction shown by co-immunoprecipitation, direct association between VCPIP1 and SPRTN in cells was confirmed by proximity ligation assay (PLA) and PLA foci signals were mostly in the nucleus and significantly increased after FA treatment (Figures 1D–1E)."
32649882
reach
"Knockdown of VCP did not change the SPRTN/VCPIP1 interaction (Figure S2J)."
32649882
reach
"We confirmed the interaction between VCPIP1 and SPRTN using co-immunoprecipitation experiments (Figures 1A–1B and S1B–S1C)."
32649882
sparser
"We confirmed the interaction between VCPIP1 and SPRTN using co-immunoprecipitation experiments ( xref – xref and xref – xref )."
32649882
sparser
"Moreover, after treating cells with three known DPC-inducing agents, FA, camptothecin (CPT) and cisplatin ( xref ), the interaction between VCPIP1 and SPRTN increased ( xref and xref – xref )."
32649882
biogrid
No evidence text available
22902628
sparser
"Our data strongly suggest that VCPIP1-SPRTN signaling axis is the key regulation in DPC repair."
32649882
sparser
"As VCPIP1-SPRTN signaling protects cells from DPC induction, it seems likely that inhibition of VCPIP1-SPRTN could be employed to sensitize cells to different kinds of DPC-inducing agents."
32649882
reach
"Moreover, after treating cells with three known DPC-inducing agents, FA, camptothecin (CPT) and cisplatin (Stingele et al., 2017), the interaction between VCPIP1 and SPRTN increased (Figures 1C and S1D–S1E)."
32649882
reach
"VCPIP1 and USP11 interact weakly with SPRTN in co-immunoprecipitating experiments, but show no (VCPIP1) or only weak (USP11) preference for SPRTN-Ub (XREF_SUPPLEMENTARY)."
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