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Statements

SPRTN binds VCPIP1. 9 / 14
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"Moreover, after treating cells with three known DPC-inducing agents, FA, camptothecin (CPT) and cisplatin ( xref ), the interaction between VCPIP1 and SPRTN increased ( xref and xref – xref )."
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"Consistent with the interaction shown by co-immunoprecipitation, direct association between VCPIP1 and SPRTN in cells was confirmed by proximity ligation assay (PLA) and PLA foci signals were mostly in the nucleus and significantly increased after FA treatment (Figures 1D–1E)."
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"Our data strongly suggest that VCPIP1-SPRTN signaling axis is the key regulation in DPC repair."
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"As VCPIP1-SPRTN signaling protects cells from DPC induction, it seems likely that inhibition of VCPIP1-SPRTN could be employed to sensitize cells to different kinds of DPC-inducing agents."
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"Knockdown of VCP did not change the SPRTN/VCPIP1 interaction (Figure S2J)."
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"VCPIP1 and USP11 interact weakly with SPRTN in co-immunoprecipitating experiments, but show no (VCPIP1) or only weak (USP11) preference for SPRTN-Ub (XREF_SUPPLEMENTARY)."
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"We confirmed the interaction between VCPIP1 and SPRTN using co-immunoprecipitation experiments (Figures 1A–1B and S1B–S1C)."
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"Moreover, after treating cells with three known DPC-inducing agents, FA, camptothecin (CPT) and cisplatin (Stingele et al., 2017), the interaction between VCPIP1 and SPRTN increased (Figures 1C and S1D–S1E)."
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sparser
"We confirmed the interaction between VCPIP1 and SPRTN using co-immunoprecipitation experiments ( xref – xref and xref – xref )."
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