IndraLab

Statements

SLC7A7 activates KCNK2. 3 / 3
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"The two-pore (2P) domain K + channels (TREK-1 and TRAAK) are also activated by LPC and LPI, while only weakly responding to small-headed LPLs (LPE and LPS) [89] ."
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"Similarly, it has been shown that LPI activates TREK channels such as bTREK-1 and bKv1.4 K + currents [ xref ]."
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"These results indicate that the effect of lysophospholipids on TREK channels is very dependent on the recording technique and warns of the extreme care that must be taken when interpreting negative results under some experimental conditions.Macroscopic currents: LPC, lysophosphatidylinositol (LPI), platelet-activating factor and Lyso-platelet-activating factor strongly activated TREK1 channels and induced a dose-dependent outward current in COS cells transfected with TREK1 channels and voltage-clamped at 0 mV."
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