IndraLab

Statements

OTULIN inhibits Syndrome. 9 / 9
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"Excessive apoptosis in the skin or intestine may disrupt these barriers and allow an influx of microbes that then drive inflammation.In humans, TNFR1-induced cell death is thought to be an important d[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"For the negative role of OTULIN in immune responses, OTULIN deficiency might cause auto-inflammatory syndrome [128]."
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"Moreover, this phenotype of Otulin -deficient mice was consistent with the clinical features of human patients with OTULIN deficiency, which causes a severe autoinflammatory syndrome termed OTULIN-rel[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Deficiency in OTU deubiquitinase with linear linkage specificity (OTULIN) causes OTULIN-related autoinflammatory syndrome (ORAS), a severe inflammatory pathology affecting multiple organs including the intestine."
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"OTULIN deficiency in humans leads to a syndrome – OTULIN-related autoinflammatory syndrome (ORAS) [67] or otulipenia [68] – consisting of neonatal-onset fever, skin rashes, and failure to thrive."
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"Most recently, it was demonstrated that haploinsufficiency of OTULIN due to heterozygous variants was associated with an increased risk of life-threatening necrosis upon staphylococcal infection, while complete OTULIN deficiency causes an auto-inflammatory syndrome [137]."
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"The deficiency of OTULIN reportedly induces autoinflammatory syndrome, and anti -TNF-α neutralizing antibodies suppressed the inflammation induced by OTULIN deficiency [21,22] ."
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"Deficiency of the linear ubiquitin chain-specific deubiquitinase, OTULIN, causes OTULIN-related autoinflammatory syndrome (ORAS), a systemic inflammatory pathology affecting multiple organs including the skin."
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"Deficiency of the linear ubiquitin chain-specific deubiquitinase, OTULIN, causes OTULIN-related autoinflammatory syndrome (ORAS) in humans."
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