IndraLab

Statements

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"OTUB1 deficiency leads to HCC cells to become more sensitive to T cell mediated cytotoxicity, inhibits tumor growth and enhances anti-tumor immunity in mice by regulating PD-L1 79, 80.When PD-1 binds to ligand, it inhibits T cell response and reduces T cell secretion of IFN-γ 61."
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"Consistently, Otub1 deletion profoundly enhances anticancer immunity through unleashing the activity of CD8 T cells and NK cells."
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"Consistently, loss of OTUB1 increases the anticancer immunity of CD8 T cells."
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"However, influenza A virus can trigger OTU1 degradation to sabotage this anti-infection mechanism.Collectively, these result suggest OTUB1 might suppress the immune response to host cells including tumor cells or normal cells."
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"There is evidence that OTUB1 represses anti-tumor immunity, innate immunity, and autoimmunity."
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"4.4.1 OTUB1 suppresses tumor immunity."
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"In addition, OTUB1 inhibits tumor immune surveillance by another mechanism."
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