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COPS6 decreases the amount of SIRT2. 7 / 7
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"On the contrary, overexpression of CSN6 reduced the expression of SIRT2 and leaded to a decrease of AMPK activation ( Fig.S2 C)."
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"In the present study, we found that overexpression of CSN6 inhibited the mRNA and protein expression of SIRT2, and SIRT2 mediated the pro-hypertrophic function of CSN6 in cardiomyocytes response to An[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In addition, CSN6 could inhibit the mRNA expression of SIRT2, this highlighted a question how dysregulation of deubiquitinase caused a transcriptional suppression."
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"Mechanistically, increased CSN6 stabilized transcription factor Nkx2.2 and then inhibiting the expression of SIRT2."
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"Moreover, we found that CSN6 inhibited SIRT2 expression by stabilizing the expression of Nkx2.2, a transcription factor which suppressed SIRT2 transcription [ 24 ]."
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"Interestingly, silencing CSN6 increased the mRNA and protein expression of SIRT2, and overexpression of CSN6 decreased the mRNA and protein expression of SIRT2( Fig. 3 B–E)."
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"Besides, silencing CSN6 not only increased the expression of SIRT2, but also leaded to the activation of AMPK ( Fig.S2 B)."
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