IndraLab

Statements

USP10 inhibits autophagy. 6 / 6
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"These findings confirm that acacetin improves cardiac remodeling by suppressing cardiomyocyte autophagy and highlight the crucial role of USP10 in the Beclin 1 ubiquitination degradation-mediated inhibition of the cardiomyocyte autophagy signaling pathway."
40118748
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"These results suggested that LC3 is degraded by autophagy in both USP10-WT and USP10-KD cells with or withoutMG-132 treatment, and that USP10-KD does not inhibit autophagy mediated degradation of LC3."
30469013
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"These results implied that the preferential cytotoxicity and UPR inhibition of spautin-1 under GS- or 2DG-stressed conditions are independent of autophagy inhibition.The USP10 and USP13 deubiquitinases have been identified as molecular targets of spautin-1 ."
35798783
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"Interestingly, Spautin-1-mediated specific and potent inhibition of deubiquitinating activity of USP10 and USP13 was shown to promote proteasomal degradation of PIK3C3 and thereby inhibit autophagy [179]."
34241570
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"Because the reductions in the levels of USP10 and USP13 in H4-LC3-GFP cells treated with spautin-1 appeared later than the reductions in the levels of Vps34 complexes and autophagy (XREF_FIG), the reduced levels of USP10 and USP13 are unlikely to be the primary reason for the ability of spautin-1 to reduce the levels of PtdIns3P and inhibit autophagy."
21962518
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"Spautin-1 inhibits deubiquitinating enzymes USP10 and USP13 and promotes degradation of the BECN1-PI3K autophagy initiation complex, which is required for canonical autophagy induction [30]."
37420311