IndraLab

Statements

SB 203580 inhibits STAT1. 3 / 4
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"Since STAT1 protein itself is shown to be accumulated upon EGF stimulation of A431 cells [7] , at first we checked whether SB203580 blocks STAT1 accumulation."
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"These results confirmed that STMN1 can promote p38MAPK/STAT1 signaling pathway activation.To explore the role of p38MAPK/STAT1 in the progression of STMN1 promoting NSCLC metastasis, SB203580 and fludarabine were used to inhibit the activation of p38MAPK/STAT1."
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"PathwayNet analysis suggested that UM101 inhibits some of the SB203580 inhibited transcription factors (STAT-1, c-Fos, c-Jun, NF-kappaB, p53, PPARgamma, and Sp1), but not others (ATF1, ATF2, Elk1, c/EBPbeta, USF1, SMAD3, FOXO1, and CREB via MSK1/2)."
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