IndraLab

Statements

USP37 binds WAPL. 15 / 15
3 | 5 7
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"Lastly, mutation of UIM2 and/or UIM3 perturbed USP37 binding to the cohesin regulator WAPL and to endogenous Ub-protein conjugates xref , xref ."
30858488
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"Because the interaction between USP37 and WAPL is dependent on the ubiquitin-binding domains of USP37, we hypothesized that USP37 may regulate WAPL’s association with chromatin and/or its stability th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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sparser
"USP37 interacts with WAPL, a negative regulator of cohesion, through its UIMs and regulates the stability of chromatin-associated WAPL."
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sparser
"However, because both USP37 and WAPL negatively regulate cohesion, we hypothesized that USP37 may interact with WAPL to facilitate sister chromatid resolution."
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"USP37 -binding mutants of WAPL revealed that the UIM2 and UIM3 domains are essential for interaction with WAPL."
| PMC
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"Indeed, GFP-WAPL co-immunoprecipitates with FLAG-USP37 in HEK293 cells ( Figure 3 D), indicating that WAPL associates with USP37."
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"WAPL is pulled down with His Ub under denaturing conditions in all tested treatments, indicating that ubiquitylated WAPL is detected throughout the cell cycle.We expected that, if USP37 deubiquitylate[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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biogrid
No evidence text available
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reach
"However, because both USP37 and WAPL negatively regulate cohesion, we hypothesized that USP37 may interact with WAPL to facilitate sister chromatid resolution."
26299517
biogrid
No evidence text available
26299517
biogrid
No evidence text available
26299517
sparser
"We expected that, if USP37 deubiquitylates WAPL, the ubiquitin-binding activities of USP37 would be critical for the interaction between USP37 and WAPL."
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reach
"To determine whether the physical association between USP37 and WAPL is dependent on the ubiquitin binding activity of USP37, the same mutations were introduced into full-length FLAG-USP37 and express[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"These results confirm the contribution of UIM2 and UIM3 of USP37 to binding ubiquitin conjugates in vitro and, in particular, to mediating an interaction with WAPL in vivo.Because the interaction betw[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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reach
"USP37 interacts with WAPL, a negative regulator of cohesion, through its UIMs and regulates the stability of chromatin associated WAPL."
26299517