IndraLab

Statements

ATXN3 activates DNAJB1. 2 / 2

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"We note that, despite gross similarity, SCA3 degeneration is not identical to general misfolding : some suppressors of Ataxin-3 toxicity strikingly enhanced dominant negative Hsp70 (upregulation of DnaJ-1 and Tpr2), whereas the enhancer CG11033 E3093 suppressed it."

17953484

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reach

"Expression of expanded ataxin-3 on all CHIP backgrounds does not increase Hsp90 or Hsp40 above wild-type levels (XREF_FIG), suggesting no major imbalance in these key chaperones."

19084066

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IndraLab

Statements

ATXN3 activates DNAJB1. 2 / 2

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