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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

ATXN3 activates DNAJB1. 2 / 2

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"We note that, despite gross similarity, SCA3 degeneration is not identical to general misfolding : some suppressors of Ataxin-3 toxicity strikingly enhanced dominant negative Hsp70 (upregulation of DnaJ-1 and Tpr2), whereas the enhancer CG11033 E3093 suppressed it."

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"Expression of expanded ataxin-3 on all CHIP backgrounds does not increase Hsp90 or Hsp40 above wild-type levels (XREF_FIG), suggesting no major imbalance in these key chaperones."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...