IndraLab

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OTUD5 decreases the amount of OTUD5. 2 / 2
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"In addition to inhibiting USP20, a recent study confirmed that 160 nM GSK2643943A also has an inhibitory effect on another DUB, ovarian tumor protease deubiquitinase 5 (OTUD5), which can increase the [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Altogether, the abovementioned findings and valuable evidence highlighted that OTUD5 exerts an anti-tumor function by means of deubiquitinating and stabilizing PTEN, while enhancing the ubiquitination of PTEN reverses the inhibition of OTUD5 overexpression on NSCLC progression.Furthermore, we focused our efforts on the upstream targets of OTUD5."
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