IndraLab

Statements

Amodiaquine inhibits autophagy. 5 / 5
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"Additionally, amodiaquine inhibited autophagy and induced apoptosis by increasing stearoyl-CoA desaturase-1 (SCD-1) and P62 expressions in A549 cells [174].3.2.4 Targeting others pathways."
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"In contrast to our results, a previous study demonstrated that amodiaquine treatment inhibited autophagy function in a melanoma cell line."
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"Interestingly, autophagy inhibition caused by amodiaquine is not involved in the inhibition of rRNA transcription, suggesting two independent anticancer mechanisms."
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"Along with the inhibition of ribosomal biogenesis , amodiaquine also inhibited autophagy ."
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"CQ, QN, MQ, and amodiaquine have been previously shown to inhibit autophagy, while the remaining antimalarial agents tested (piperaquine, primaquine, and artemisinin) have not to our knowledge."
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