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USP38 deubiquitinates NFkappaB. 1 / 1
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"Mechanistically, USP38 interacted with and deubiquitinated nuclear factor-kappa B (NF-kappaB), and USP38 overexpression increased the level of p-NF-kappaB in vivo and in vitro, accompanied by the upregulation of NOD-like receptor protein 3 (NLRP3) and inflammatory cytokines, suggesting that USP38 contributes to adverse effects by driving NF-kappaB/NLRP3-mediated inflammatory responses."