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Bafilomycin A1 inhibits NLRP3. 2 / 2

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"Previously, we demonstrated that blockade of the intracellular clearance systems in human retinal pigment epithelial (RPE) cells by MG-132 and bafilomycin A1 (BafA) induces NLRP3 inflammasome signaling."

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"Whether Bafilomycin A1 inhibition of NLRP3 inflammasome activity with silica exposure is due to direct inhibition of LMP, or inhibition of the activation of cathepsin B, is not known."

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Statements

Bafilomycin A1 inhibits NLRP3. 2 / 2

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