IndraLab

Statements

USP22 deubiquitinates H2BK120ub. 3 / 3
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"USP22 is involved in the deubiquitylation of H2BK120ub, a mark that is found at DSB sites, USP22 could be a “reader” for this mark and potentiate the recruitment of other DNA damage factors through this ubiquitin mark."
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"14 , 38 To detect whether USP22 participates in the deubiquitination of H2AK119ub and H2BK120ub during Sorafenib‐induced ferroptosis, we initially conducted Western blotting to assess the levels of H2AK119ub and H2BK120ub in USP22 knockout or control cells treated with DMSO or Sorafenib."
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"Other major DUBs with specificity for histone H2AK119ub over H2BK120ub are BAP1 and USP16, while USP3, USP12, USP22, and USP44 deubiquitinate both H2AK119ub and H2BK120ub, as well as different non histone substrates [XREF_BIBR]."
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