IndraLab

Statements

BAP1 deubiquitinates KLF5. 7 / 7
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"Compared with GST and BAP1-C91S, BAP1 specifically decreased KLF5 polyubiquitination (XREF_FIG; XREF_SUPPLEMENTARY)."
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"BAP1 interacts directly with KLF5 and stabilizes KLF5 via deubiquitination."
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"In breast cancer cell lines, BAP1 plays an oncogenic function by directly deubiquitinating and stabilizing KLF5 (Kruppel-like factor 5)."
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"BAP1, but not BAP1-C91S, markedly decreased KLF5 protein polyubiquitination (XREF_FIG, lanes 3 and 4), whereas another DUB, A20, did not decrease KLF5 polyubiquitination (XREF_FIG, lane 5)."
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"Second, BAP1 decreases KLF5 polyubiquitination and increases KLF5 protein stability in a DUB activity dependent manner."
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"BAP1 antagonizes WWP1 mediated transcription factor KLF5 ubiquitination and inhibits autophagy to promote melanoma progression."
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"Finally, we demonstrated that knockdown of endogenous BAP1 increased the ubiquitination of endogenous KLF5 in HCC1806 (XREF_FIG)."
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