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BAP1 deubiquitinates KLF5. 8 / 9
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"For instance, BAP1 deubiquitinates and stabilizes the transcription factor KLF5, which is highly expressed in breast cancer and a potent biomarker for unfavorable prognosis in breast cancer patients, and promotes breast cancer cell proliferation, survival, and migration as well as tumor growth ."
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"In breast cancer cell lines, BAP1 plays an oncogenic function by directly deubiquitinating and stabilizing KLF5 (Kruppel-like factor 5)."
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"BAP1 has been reported to promote breast cancer cell proliferation and metastasis by deubiquitinating KLF5 [ 18 ]."
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"BAP1, but not BAP1-C91S, markedly decreased KLF5 protein polyubiquitination (XREF_FIG, lanes 3 and 4), whereas another DUB, A20, did not decrease KLF5 polyubiquitination (XREF_FIG, lane 5)."
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"Compared with GST and BAP1-C91S, BAP1 specifically decreased KLF5 polyubiquitination (XREF_FIG; XREF_SUPPLEMENTARY)."
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"Finally, we demonstrated that knockdown of endogenous BAP1 increased the ubiquitination of endogenous KLF5 in HCC1806 (XREF_FIG)."
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"Second, BAP1 decreases KLF5 polyubiquitination and increases KLF5 protein stability in a DUB activity dependent manner."
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"Notably, KLF5 is de-ubiquitylated by BRCA1 associated protein-1 (BAP1) (Jia et al. 2021; Qin et al. 2015) and suppresses autophagy by activating the PI3K-AKT-mTOR signaling (Jia et al. 2021) that can inhibit the autophagy initiation and the autophagosome formation via modulating the activity of AMBRA1 and ULK1 complex (Xu et al. 2020; Nazio et al. 2013)."
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