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TNF activates KCNH2. 2 / 2

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"Besides, it has been demonstrated that hERG is negatively modulated by hyperglycemia, tumor necrosis factor, ceramide and reactive oxygen species which are cellular metabolites accumulated in diabetic tissues [XREF_BIBR, XREF_BIBR]."

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"Moreover, Wang and coll showed that TNFalpha down-regulates in vitro IKr by impairing the function of the hERG potassium channel via the stimulation of reactive oxygen species."

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TNF activates KCNH2. 2 / 2

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