IndraLab

Statements

KCNH1 activates angiogenesis. 9 / 9
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"Our previous studies provide evidence that Eag1 promotes the growth and angiogenesis of OS and the downreguation of Eag1 by siRNA or microRNA-34a exhibited antitumor effects on OS [XREF_BIBR, XREF_BIBR]."
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"A study has identified the role of miR-296-3p in targeting ether-à-go-go (EAG1) to regulate cell growth in human glioblastoma [56], while EAG1 can promote tumor angiogenesis by increasing HIF1 activity [57]."
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"XREF_BIBR, XREF_BIBR In addition, Eag appears to induce tumor angiogenesis by the induction of functional increase of hypoxia inducible factor-1 (HIF-1) and the secretion of vascular endothelial growth factor (VGEF) upon hypoxia XREF_BIBR and participates in the acquisition of malignant phenotypes in lung tumor cell."
23450231
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"Taken together, our results suggest that Eag1 silencing inhibits tumor growth and angiogenesis in osteosarcoma via the down regulation of VEGF/PI3K/AKT signaling."
23202914
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"Eag1 Silencing Inhibits Angiogenesis of Xenografted Osteosarcoma."
23202914
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"Eag1 expression interferes with hypoxia homeostasis and induces angiogenesis in tumors."
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"Furthermore, some K + channels proved to play an important role for angiogenesis: for example Eag1 was shown to increase HIF1α activity and angiogenesis [117] ."
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"Collectively, this study provides the first lines of evidence that Eag1 silencing inhibits tumor growth and angiogenesis in osteosarcoma and these are associated with the downregulation of VEGF/PI3K/AKT signaling."
23202914
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"Eag1 appears to induce tumor angiogenesis by the release of hypoxia inducible factor-1 (HIF-1) and vascular endothelial growth factor (VEGF) upon hypoxia [XREF_BIBR]."
23202914