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UCHL3 activates GARS1. 5 / 5
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"Furthermore, we wondered how UCHL3 modulated the function of SMAD1 in BMSCs."
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"These results suggest that the reduction of Uch-L3 decreases the active pSmad1 signal and thus reduces the osteoblast differentiation.This study showed a novel function for Uch-L3 in osteoblast differ[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Moreover, although we found that MS-BMDM-derived exosomal UCHL3 promotes BMSCs osteogenesis by targeting SMAD1, additional questions, such as binding sites, still require clarification."
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"This study suggests that mechanical force-induced macrophage-derived exosomal UCHL3 promotes BMSCs osteogenesis by targeting SMAD1, thereby promoting alveolar bone formation during OTM."
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"MS-BMDM-derived exosomal UCHL3 promotes BMSCs osteogenesis by targeting SMAD1."
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