IndraLab

Statements

COPS5 increases the amount of SIAH1. 5 / 5
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"The data in Fig. 4 suggested that CSN5 would enhance SIAH-1 expression."
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"In this study, we have observed that CSN5 effectively modulated SIAH-1 levels by different mechanisms."
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"Silencing RNA knockdown or overexpression of CSN5 revealed that CSN5 promotes SIAH-1 expression, while CSN5 knockdown also attenuated SIAH-1 protein degradation."
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"Further investigation on molecular targets revealed that silencing of Jab1 obviously increased the p53 protein level thereby promoting the transcription of ubiquitin ligase Siah1 (Seven in absentia homolog 1), which aggravates the degradation of beta-catenin."
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"This is counter-intuitive at first sight, as it suggested that CSN5 both promotes SIAH-1 expression and degradation."
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