IndraLab

Statements

KCNH2 activates Ala-Pro. 3 / 3
| 3
reach
"Consistent with this notion, accelerated I Kr / hERG deactivation (as a response to extracellular acidosis) has previously been shown to reduce the protective role of I Kr early in diastole and decrease AP excitation threshold in a human ventricular AP model."
33475719
reach
"The authors showed that the R311C mutation specifically disables the posttranscriptional activity of TBX20 over KCNH2, which decreases the I Kr and prolongs the AP, therefore, identifying TBX20 as an LQT2 modifying gene [XREF_BIBR]."
28573431
reach
"The addition of the hERG blocker E-4031 and the sodium channel modulator veratridine significantly prolonged the AP duration."
20407085