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SUMO3 binds OTUB2. 8 / 8
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"Indeed, while purified YAP and TAZ wild-type directly associated with OTUB2-SUMO3 chimera, whereas the SIM3A mutants of YAP or TAZ could not ( Figure 6 D)."
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"In line with the above findings, the OTUB2-SUMO3 chimera more efficiently increased the stability of YAP/TAZ than OTUB2-WT, whereas OTUB2-K233R was much less efficient to stabilize YAP/TAZ ( Figures S[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Analysis of OTUB2 self-deubiquitination and the activity for Ubiquitin-AMC showed that both OTUB2-K233R and the OTUB2-SUMO3 chimera displayed similar deubiquitinating activity ( Figures S5 C and S5D),[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Moreover, expression of OTUB2-WT or OTUB2-SUMO3 could not increase mammosphere numbers in cells expressing YAP/TAZ-SIM3A ( Figures S6 F and S6G), indicating that the SIM of YAP/TAZ is required to func[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Moreover, although purified YAP/TAZ could not directly interact with OTUB2-WT in vitro , it did bind OTUB2-SUMO chimera that might mimic SUMOylation (OTUB2-SUMO3; Figure 5 B)."
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"Furthermore, breast cancer cells stably expressing the OTUB2-SUMO3 chimera showed more mammospheres and CD44 high /CD24 low stem-like cells, whereas OTUB2-K233R expression had the opposite effect ( Fi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Consistent with this, YAP/TAZ ubiquitination was not reduced by OTUB2-K233R, whereas the OTUB2-SUMO3 chimera was more active than OTUB2-WT to reduce YAP/TAZ ubiquitination ( Figures 5 C, 5D, S5 A, and[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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