IndraLab

Statements

Caspase activates ATXN3. 7 / 7
| 7
reach
"Finally, caspase mediated cleavage of expanded ataxin-3 resulted in increased ataxin-3 aggregation, suggesting a potential role for caspase mediated proteolysis in spinocerebellar ataxia type-3 pathogenesis."
15140190
reach
"A recent publication reported involvement of CDK5 in caspase mediated ataxin-3 cleavage, showing that RNAi of CDK5 in a Drosophila model for SCA 3 resulted in an enhanced SCA 3 toxicity [XREF_BIBR]."
25309920
reach
"CDK5 protects from caspase induced Ataxin-3 cleavage and neurodegeneration."
24548080
reach
"Moreover, caspase-mediated proteolytic cleavage of ataxin-3 at D241, D244, and D248 leads to the formation of toxic ataxin-3 fragments ( Liman et al., 2014 ; Shoesmith Berke et al., 2004 )."
33775891
reach
"In line with previous research, there was no increased caspase mediated cleavage of expanded ataxin-3 compared to non expanded ataxin-3."
27731380
reach
"Whether caspase mediated ataxin-3 cleavage is indeed a major contributor to SCA3 pathogenesis remains to be determined through future in vivo experiments."
27731380
reach
"Berke et al. [56] showed that caspase-mediated cleavage of expanded ataxin-3 resulted in increased ataxin-3 aggregation, suggesting a potential role for caspase-mediated proteolysis in SCA-3 pathogene[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23684638