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OTUB1 deubiquitinates SLC7A11. 9 / 9
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"Mechanism research expounded that circ-BGN directly bound to OTUB1 and SLC7A11 and boosted SLC7A11 deubiquitination mediated by OTUB1, thus suppressing ferroptosis and further enhancing trastuzumab resistance in HER2-positive BC [91]."
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"Circ-BGN is overexpressed in breast cancer and contributes to trastuzumab resistance by suppressing cell ferroptosis through inducing deubiquitination of SLC7A11 mediated by OTUB1, leading to poor OS."
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"In this study, we utilized biochemial purification to identify the ubiquitin hydrolase <span class="match term0">OTUB1</span> as a key factor in modulating <span class="match term1">SLC7A11</span> stability"
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"Moreover, MARCHF6 E3 upregulates SLC7A11 expression by promoting p53 degradation [ 8 ], whereas OTUB1 deubiquitylates SLC7A11 for stabilization [ 52 ]."
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"On the contrary, OTU domain-containing ubiquitin aldehyde-binding proteins otubain 1 (OTUB1) suppresses xCT ubiquitination, enabling cells tolerant to ferroptosis58."
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"Conversely, the deubiquitinating enzymes OTUB1 and ubiquitin specific peptidase 20 (USP20) mediate the deubiquitination of SLC7A11, thereby stabilizing SLC7A11 levels in cancer cells [6,122]."
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"Furthermore, circ-BGN can directly bind to OTUB1 and SLC7A11, enhancing the deubiquitination of SLC7A11 mediated by OTUB1, which subsequently inhibits ferroptosis."
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"Therefore, Circ-BGN enhances OTUB1-mediated deubiquitination of SLC7A11 and upregulates SLC7A11 protein expression to inhibit ferroptosis [123]."
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"OTUB1 deubiquitinates and stabilizes the SLC7A11 protein by direct interaction [41]."
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