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Estrogen activates KCNMA1. 6 / 6
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"The coupling between membrane receptors and MaxiK channels has been mostly studied in smooth muscle where muscle relaxants like beta-adrenergic agents and estrogen induce MaxiK channel activation and constrictors like Acetylcholine, Thromboxane A2, and Angiotensin II result in channel inhibition."
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"Gestational hypoxia also suppresses the expression of ERα in uterine arteries through hypermethylating the Erα-encoding gene ESR1, which could in turn impairs pregnancy- and estrogen-induced BK channel β1 subunit upregulation [318,319,320]."
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"These data suggest that estrogen deficiency by removing ovaries upregulates KCa1.1 channel protein in Ah-type BRNs, and subsequently increases AP repolarization and blunts neuroexcitation through estrogen membrane receptor signaling."
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"Therefore, (xeno)estrogen modulation of BK channel kinetics is conserved among avian and mammalian isoforms and can be extended to include both Tx and ICI-182,780."
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"Estrogen (such as 17 β-estradiol) is able to regulate the expression of BK channel subunits via estrogen receptors ( Li and Qiu, 2015 ) and directly activates BK channel to reduce urinary bladder smoo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Furthermore , BK channels can be modulated by estrogens such as 17beta-Estradiol ( E2 ) , when alpha subunit is co-expressed with the beta1 subunit ( Valverde et al ., 1999 ; De Wet et al ., 2006 ; Granados et al ., 2019 ) ."
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