IndraLab

Statements

USP22 binds MDM4. 14 / 16
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"Our data suggest that MDMX directly binds to USP22 in NSCLC cells."
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"Our co-immunoprecipitation analysis shows that USP22 interacts with MDMX in NSCLC cells."
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"MDMX Directly Binds to USP22 in NSCLC Cells."
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"These data indicate that MDMX directly binds to Flag-tagged USP22 in A549-USP22 cells."
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"Furthermore, we confirmed that MDMX directly interacts with endogenous USP22 in NCl-H460 cells, as MDMX was detected in USP22 immunoprecipitates and vice versa ( xref C,D)."
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"To investigate the interaction between MDMX and USP22, co-immunoprecipitation analysis was performed in NSCLC cell lines."
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"Furthermore, we confirmed that MDMX directly interacts with endogenous USP22 in NCl-H460 cells, as MDMX was detected in USP22 immunoprecipitates and vice versa (XREF_FIG C, D)."
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"Our data suggest that MDMX directly binds to USP22 in NSCLC cells."
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"Our co-immunoprecipitation analysis shows that USP22 interacts with MDMX in NSCLC cells."
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"USP22 interacts with MDMX and leading to the inhibition of p53 dependent apoptosis [29]."
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"MDMX Directly Binds to USP22 in NSCLC Cells."
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"The interaction between USP22 and MDMX in NSCLC cells was studied using co-immunoprecipitation."
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"To investigate the interaction between MDMX and USP22, co-immunoprecipitation analysis was performed in NSCLC cell lines."
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"The mechanism by which USP22 promotes NSCLC tumorigenesis is that USP22 can directly bind and upregulate MDMX (E3 ubiquitin ligase) in NSCLC cells and subsequently inhibit the P53 pathway to promote NSCLC tumorigenesis (76) ( Table 1 )."
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