IndraLab

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USP6 leads to the deubiquitination of GLS. 4 / 4
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"Similarly, umbilical cord mesenchymal cell-derived exosomes were proven able to promote Imatinib-induced apoptosis in K562-R cells via miR-146a-5p and its target USP6, which suppress GLS1 ubiquitination, causing an increase in GLS protein (78)."
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"Additionally, USP6 also inhibited GLS1 and CD147 ubiquitination, resulting in the inhibition of apoptosis and increased production of MMP."
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"Studies have shown that USP6 suppresses GLS1 ubiquitination, resulting in an increase in GLS1 protein levels."
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"Overexpression of USP6 reduces GLS1 ubiquitination, preventing breakdown and allowing for continued glutamine metabolism [52]."
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