IndraLab

Statements

COPS5 inhibits TGFB. 7 / 8
| 7
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"Jab1 antagonizes TGF-b signaling by inducing Smad4 degradation."
21913798
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"Jab1 associates with Smad7 to promote its degradation (Kim et al. 2004) although Jab1 can antagonize TGF-b signaling through its promotion of Smad4 degradation (see above) (Wan et al. 2002)."
21913798
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"By degrading Smad4 or Smad7, Jab1 can repress or increase TGF-beta and BMP signaling, respectively, in vitro."
24604556
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"Jab1 antagonizes TGF-beta function by inducing uniquitin mediated degradation of Smad4."
24127404
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"Since we observed lower expression of TGF-β1 in nasal polyposis, this may be the consequences of Smad4 dependent Jab1 activation which causes the inhibition of TGF-β1 signaling in NP."
21466889
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"Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation."
11818334
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"Our data suggest that Jab1 antagonizes TGF-beta function by inducing degradation of Smad4 through a distinct degradation pathway."
11818334