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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

CLOCK activates SCN5A. 1 / 1

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"A weak oscillator in U2OS cells can only in part explain the low number of robustly cycling genes in U2OS cells since the U2OS clock is sufficiently strong to support transcription rhythms of the ATG3, EIF5A2, and SCN5A reporters with absolute amplitudes (peak - trough) equal or higher than those of the BMAL1 and PER2 promoters."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...