IndraLab

Statements

USP37 is ubiquitinated. 8 / 8
| 8
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"As shown in xref , compared with cells expressing USP37 WT, more ubiquitinated USP37 was detected in cells expressing the USP37 CS mutant."
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"The level of USP37 ubiquitination was also reduced by mutations in UIM2 or UIM3, suggesting their role in ubiquitination of USP37 itself."
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"This regulation is achieved, in part, by association with the E3 ubiquitin ligases APC CDH1 and SCF βTrCP which drives the ubiquitylation and degradation of USP37 [ xref ], although how USP37 degradation regulates mitotic entry remains to be elucidated."
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"The level of USP37 ubiquitination is also reduced by mutations in UIM2 or UIM3, suggesting that they play a role in the ubiquitination of USP37 itself."
| PMC
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"Ubiquitination of USP37 relied on a KEN box degron located between its C-terminal UIMs ( Figure S4 A)."
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"Furthermore, UIM2 and UIM3, which are located in tandem with an eight–amino acid spacer in the region between the cysteine and histidine boxes, play an essential role in ubiquitin-binding ubiquitination of USP37, and most importantly the full catalytic activity of USP37."
| PMC
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"We believe that inappropriate APC CDH1 activity results in USP37 ubiquitination and degradation, which shifts the balance in favor of cyclin A being a substrate rather than an inhibitor of the APC/C.[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"To assess USP37 ubiquitination, HeLa cell lysates were prepared in NP-40 buffer and denatured by boiling for 10 min after addition of 1% v/v SDS."
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