IndraLab

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USP9X leads to the deubiquitination of BRCA1. 2 / 2

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"Immunoblotting analysis showed that USP9X knockdown significantly increased the ubiquitination of BRCA1 protein (Figure 2D).3.3 USP9X interacts with BRCA1."

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"Collectively, these results establish USP9X as a deubiquitinase for BRCA1 and reveal a previously unrecognized role of USP9X in the regulation of HR repair and the sensitivity of cancer cells to DNA-damaging agents."

31512408

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IndraLab

Statements

USP9X leads to the deubiquitination of BRCA1. 2 / 2

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