IndraLab

Statements

eidos
"USP4 was found to enhance DNA double-strand breaks repairment , DNA-end resection and homologous recombination via a conversed and specific domain to form a complex with CtIP and the MRE11-RAD50-NBS1 complex which can be abrogated by USP4 auto-deubiquitination on several specific cysteine residues ."
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"USP4 can also be self-deubiquitylated to promote homologous recombination [44]."
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"Existing studies have shown that auto-deubiquitylation of USP4 enhances its interaction with CtIP/MRN, thereby promoting homologous recombination (33)."
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