IndraLab

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USP18 activates pyroptosis. 5 / 5
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"Our recent discovery reveals that the depletion of ubiquitin-specific protease 18 (USP18), a major negative regulator of IFN signaling, selectively induces cancer cell ICD, specifically pyroptosis (185, 186)."
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"USP18 down-regulates the protein abundance of GSDMD, thereby inhibiting the activation of GSDMD and pyroptosis (Fig. 7)."
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"This study determined the mechanism by which targeting USP18 induces cancer pyroptosis through activating the production of a group of atypical IFN stimulated genes (ISGs) in addition to conventional ISGs [182]."
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"Here, we showed that USP18, a major suppressor of IFN signaling, protects malignant cells from IFN-induced pyroptosis by suppressing the expression of canonical and non-canonical ISGs."
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"Further dissection of the ICD phenotype in murine and human cells revealed that IFN treatment of USP18 depleted cells induced (1) NLRP3 inflammasome-Caspase-1-GSDMD-mediated canonical pyroptosis and (2) Caspase-3-GSDME-mediated non-canonical pyroptosis."
36646704