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COPS5 inhibits RAS. 2 / 2
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"Furthermore, the phosphorylation of certain substrates of Akt was enhanced in cells deprived of CSN5 ( Fig. 3 C), demonstrating that substrates of Akt as well as Akt kinase itself were phosphorylated [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Interestingly, the level of p21 was slightly raised in these p53-null cells, probably due to the massive inactivation of cullin-containing ubiquitin ligases.Because we previously showed that MAP kinas[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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