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TGFB1 phosphorylates TGFBR1. 12 / 14
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"According to xref I–J, TGF-β1 enhanced TGFBR1 phosphorylation as well as the corresponding downstream molecules."
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"TGF-beta1 could significantly increase the phosphorylation of TbetaRI (P < 0.05), whereas SO 2 treatment markedly attenuated serine phosphorylation of TbetaRI (P < 0.05)."
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"TGFbeta1 signaling is initiated by binding to the constitutively active type II serine threonine kinase receptor which, in turn, recruits and phosphorylates the type I receptor, the so called activin receptor like kinese 5, ALK5 32."
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"When the TGF-β signaling pathway is activated, TGF-β1 first binds to the TGFBR2 and phosphorylates TGFBR1."
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"Interestingly, TGF-beta1 promoted TbetaRI phosphorylation in VSMCs, while AAT1 or AAT2 overexpression indeed downregulated the TGF-beta1-induced TbetaRI phosphorylation (XREF_FIG)."
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"As shown in Fig.6B , F–H, TGF-β1 promoted the phosphorylation of TGFBR1 and its downstream signaling molecules phospho-Smad2, phospho-Smad3 levels, while the total TGFBR1, Smad2 and Smad3 expression w[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The binding of TGF-beta1 to a type II TGF-beta receptor causes the recruitment and phosphorylation of TGF-beta receptor type I, which in turn recruits and phosphorylates the receptor regulated Smad2/3[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Binding of TGFbeta1 to TbetaRII, a cell surface TGFbeta1 receptor, phosphorylates TbetaRI, which subsequently phosphorylates Smad2 and Smad3 for the induction of fibrogenic response [53]."
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"Abbreviations CNS ECM CS-PGs GAG 3-D DRG RPTWB O-2A TGFb EGF TGFclcentral nervous system extracellular matrix chondroitin sulphateproteoglycans glycosaminoglycan three- dimensional [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"TGF-β1 binds to the Type II receptor at the cell surface and recruits and phosphorylates the Type I receptor."
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"The SEB staphylococcal enterotoxin B XlYl motif (using single-letter code for amino acids), TGF-p transforming growth factor p needed for the binding of CD28 and (:?,A--! to B7 lig- ands, is not[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Sal B treatment attenuated TGF-β1-induced TβR-I and Smad2/3 phosphorylation and up-regulated Smad7 expression in HK-2 cells."
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