IndraLab

Statements

BAP1 binds HCFC1 and YY1. 7 / 7
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"31 Further, BAP1 forms a protein complex with the host cell factor 1 and Yin and Yang 1."
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"3,10,12 BAP1 and HCF-1 can also form a complex with the transcription factor YY1, which recruits BAP1 and HCF-1 to various promoters to regulate gene expression."
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"Finally, BAP1 forms complexes with the transcription factors Yin Yang 1 (YY1) and host cell factor 1 (HCF-1), and controls cell-cycle progression at G1/S by co-regulating transcription from HCF-1/E2F-governed promoters [ xref , xref ]."
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"BAP1 forms a ternary complex with HCF1 and YY1, which acts as transcriptional repressor of genes involved in cell proliferation ( xref )."
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"Prominent among the positively enriched gene sets were those related to writers of histone H3K27Me3, including PRC2 and SUZ12 (XREF_FIG), as well as genes participating in cell proliferation and transcription regulation involving ubiquitin signaling mediated by the Bap1, HCF1, and YY1 complex, EED related stem cell pluripotency, cytokine signaling, and cell adhesion; 100 of the top pathways differentially affected in MMs from TKO versus DKO mice are presented in XREF_SUPPLEMENTARY."
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"Our RNA-seq analysis revealed that MMs from Bap1; Nf2; Cdkn2a CKO mice exhibit positively enriched gene sets consistent with cellular processes previously implicated in Bap1 function, such as genes mediated by the Bap1, HCF1, and YY1 complex, which play a role in cellular proliferation and transcription regulation involving ubiquitin signaling."
31151962
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"Yu H, Mashtalir N, Daou S, et al. The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expression."
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