IndraLab

Statements

TCF_LEF binds LEF1 and CTNNB1. 11 / 11
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"The β-catenin proteins then translocate to the nucleus via BCL9 and Pygo1 [ xref ] where β-catenin interacts with the T-cell factor (TCF) and lymphoid enhancer factor (LEF) transcriptional activators resulting in upregulation of TCF/LEF target genes."
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"As a TF, β-catenin assembles with the DNA-binding proteins TCF and LEF-1 to activate genes that drive cell proliferation."
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"In NLK-knockout cells, there is a constitutive interaction between Lef1 and β-catenin, which could explain the elevated Tcf/Lef promoter activity in these cells."
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"The inactivation of GSK-3β and the subsequent stability and nuclear translocation of β-catenin and formation of a Lef1–Tcf–β-catenin complex plays a fundamental role for the differentiation of the HM cells into the precortical HM and HS ( xref ; xref )."
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"Nuclear CTNNB1 binds the transcription factors LEF1 (lymphoid enhancer-binding factor 1) and TCF (T-cell factor), thereby converting LEF1 into a transcriptional activator ( xref )."
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"Buscarlet and colleagues demonstrated that active β-catenin binds to TCF/Lef at a site on Lef-1, where it displaces Groucho/TLE, which overlaps with the Lef-1-binding site. xref Other reports have shown that the modification of TLE by XIAP-mediated ubiquitylation decreases its affinity with β-catenin, thereby allowing the formation of the β-catenin/TCF complex and thus the switch to an activated Wnt signaling pathway. xref The molecular mechanism by which NDRG1 functions in ESCC remains unclear."
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"Promoter methylation of the Wnt target OVOL2 has an additional effect: In healthy tissue, OVOL2 recruits HDAC1 to the CTNNB1/TCF/LEF1 complex, resulting in inhibition of proliferative target gene expr[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"This allows the formation of complexes of β-catenin with TCF or LEF1, two closely related transcription factors, which then translocate into the nucleus and regulate target gene transcription in response to Wnt ligands."
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"Β-catenin forms complexes with Tcf and Lef-1 and functions as a transcriptional activator in the Wnt signalling pathway."
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"When the Wnt signaling pathway is activated, β-catenin interacts with the TCF and lymphoid enhancer–binding factor (LEF) in the nucleus."
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"Therefore, this part of the study will focus on more general epigenetic mechanisms that regulate target genes.Both the GLI family members and the CTNNB1/TCF/LEF1 complex recruit factors to the DNA, re[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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