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KCNH2 inhibits astemizole. 4 / 4
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"In contrast with findings described by others (Matsa etal, 2011), hERG modulation by LUF7346 completely reversed the severe effects of the potassium channel blocker AST in LQT2 N996I hiPSC-CMs, confirming the efficacy of LUF7346 compared to other molecules reported so far in the literature."
27470144
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"A rapid, highly specific, and reproducible arrhythmia was induced by the following HERG blocking compounds: H1-receptor antagonists: astemizole, terfenadine, diphenhydramine, and orphenadrine; psychot[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
14678746
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"Effects of 15 torsadogenic hERG blocking drugs (astemizole, chlorpromazine, cisapride, droperidol, ibutilide, dofetilide, haloperidol, moxifloxacin, pimozide, quinidine, risperidone, sotalol, sertindole, terfenadine, thioridazine) were assessed by telemetry in beagle dogs."
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"High-affinity hERG channel blocking drugs E4031, astemizole, cisapride and quinidine all produced reverse effects, and the rescue was dependent on their interaction with F656."
27690007