IndraLab

Statements


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"Effects of 15 torsadogenic hERG blocking drugs (astemizole, chlorpromazine, cisapride, droperidol, ibutilide, dofetilide, haloperidol, moxifloxacin, pimozide, quinidine, risperidone, sotalol, sertindole, terfenadine, thioridazine) were assessed by telemetry in beagle dogs."

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"High-affinity hERG channel blocking drugs E4031, astemizole, cisapride and quinidine all produced reverse effects, and the rescue was dependent on their interaction with F656."