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CYLD activates cell cycle. 6 / 6
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"The CYLD mediated deubiquitylation of certain substrates can affect different phases of the cell cycle, and ultimately, cellular proliferation.BCL3 was originally identified in a subgroup of B cell le[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In turn, acetylated α-tubulin promotes CYLD translocation to the perinuclear region, where CYLD induces a delay in the G1/S transition of the cell cycle through a BCL-3-mediated pathway."
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"A recent study has shown that CYLD overexpression in PC-3 cells promoted the ubiquitination of NoxO1 protein, shortened its half-life, inhibited ROS production and modulated cell cycle [31]."
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"The increased expression of CYLD triggers cell cycle arrest and apoptotic induction [36]."
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"Therefore, CYLD contributes to control of the cell cycle at different stages: during G1/S transition phase, mitosis and cytokinesis."
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"In a different study of HDAC6 and its role in tumorigenesis, it was found that CYLD mediated inhibition of HDAC6 was essential for CYLD activation and delay in the cell cycle."
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