IndraLab

Statements

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"In our genetically engineered mouse model, USP13 overexpression promoted ovarian tumorigenesis and metastasis [14]."
36612196
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"Ubiquitin-specific Peptidase 13 (USP13) is highly amplified and promotes tumorigenesis and metastasis in ovarian cancer."
36612196
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"USP13 is highly amplified in human ovarian cancer, and elevated expression of USP13 promotes tumorigenesis and metastasis of ovarian cancer."
36612196
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"USP13 knockdown impaired the tumorigenesis of GC cells in vivo."
37311811
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"To investigate whether USP13 knockdown suppressed the tumorigenesis of GC cells in vivo, we injected MKN-45 GC cells which were stably knocked-down USP13 (shUSP13) or the negative control (shNC) into the subcutaneous of the nude mice."
37311811
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"Importantly, overexpression of Usp13 accelerates tumorigenesis, enhances tumor metastasis, and causes poor outcomes in transgenic mouse models of ovarian cancer , underscoring its importance in promoting tumorigenesis in vivo."
36385557
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"In vitro and in vivo depletion of USP13 inhibited SCLC cancer stem cells (CSCs) properties and tumorigenesis, and this inhibitory effect was rescued by reconstituted expression of wide type (WT) USP13 but not the enzyme-inactive USP13 mutant."
35898882
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"More importantly, the small molecule inhibitor of FASN, TVB-2640, significantly inhibits lipogenic phenotype and attenuates self-renewal ability, chemotherapy resistance and USP13-mediated tumorigenesis in SCLC."
35898882
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"Overexpression of USP13 with deletion of Trp53 and Pten in murine ovarian surface epithelium accelerated ovarian tumorigenesis and led to decreased survival in mice."
35173307